Mega2: data-handling for facilitating genetic linkage and association analyses
نویسندگان
چکیده
منابع مشابه
Mega2: data-handling for facilitating genetic linkage and association analyses
UNLABELLED Mega2, the manipulation environment for genetic analysis, transparently allows users to process genetic data for family-based or case/control studies accurately and efficiently. In addition to data validation checks, Mega2 provides analysis setup capabilities for a broad choice of commonly used genetic analysis programs, including SimWalk2, ASPEX, GeneHunter, SLINK, SIMULATE, S.A.G.E...
متن کاملMethods for Genetic Linkage Analyses
Reports of the mapping and cloning of genes appear regularly in the major newspapers and lay magazines. The catalog of mapped and cloned human genes is being produced biannually as the report of the Human Gene Mapping workshops. In the latest report (McAlpine et al., 1988), over 1200 genes were hsted, of which half were c loned and over 2400 res t r ic t ionlength polymorphic locations were ide...
متن کاملLinkage and association analyses of principal components in expression data
Performing linkage and association analyses on a large set of correlated data presents an interesting set of problems. In the current setting, we have 3554 expression levels from lymphoblastoid cell lines in 194 individuals from 14 three-generation Utah CEPH (Centre d'Etude du Polymorphisme Humain) pedigrees. We formed multivariate expression phenotypes from six sets of genes. These consisted o...
متن کاملGenetic loci for blood lipid levels identified by linkage and association analyses in Caribbean Hispanics.
To identify genetic loci influencing blood lipid levels in Caribbean Hispanics, we first conducted a genome-wide linkage scan in 1,211 subjects from 100 Dominican families on five lipid quantitative traits: total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), triglycerides (TG), and LDL-C/HDL-C ratio. We then investigated the associa...
متن کاملSelection of genetic markers for association analyses, using linkage disequilibrium and haplotypes.
The genotyping of closely spaced single-nucleotide polymorphism (SNP) markers frequently yields highly correlated data, owing to extensive linkage disequilibrium (LD) between markers. The extent of LD varies widely across the genome and drives the number of frequent haplotypes observed in small regions. Several studies have illustrated the possibility that LD or haplotype data could be used to ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Bioinformatics
سال: 2005
ISSN: 1367-4803,1460-2059
DOI: 10.1093/bioinformatics/bti364